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Convulsive seizures and peripheral neuropathy, the latter characterized predominantly by numbness or paresthesia of an extremity, are already described in sufferers taken care of with oral or intravenous metronidazole.
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Slight (one)metronidazole topical will increase the stage or impact of ethanol by reducing metabolism. Small/Significance Unfamiliar. Disulfiram-like response with oral metronidazole and alcohol; not as likely to take place with vaginal administration due to reduced absorption
There have been no knowledge to date with the usage of METROGEL-VAGINAL in pregnant sufferers. Metronidazole crosses the placental barrier and enters the fetal circulation speedily. No fetotoxicity or teratogenicity was observed when metronidazole was administered orally to pregnant mice at 6 situations the proposed human dose (depending on mg/m²); nonetheless, in only one smaller examine the place the drug was administered intraperitoneally, some intrauterine deaths have been noticed. The connection of these conclusions towards the drug is unknown.
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Use of cimetidine jnetoto with oral metronidazole may perhaps prolong the half-everyday living and decrease plasma clearance of metronidazole.
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